{"id":18341,"date":"2019-07-25T19:42:31","date_gmt":"2019-07-26T02:42:31","guid":{"rendered":"https:\/\/www.vitalhealth.com\/?p=18341"},"modified":"2019-07-26T11:13:02","modified_gmt":"2019-07-26T18:13:02","slug":"stages-of-endo-2-2","status":"publish","type":"post","link":"https:\/\/www.vitalhealth.com\/endo-blog\/key-cause-of-pelvic-pain-for-women-with-endometriosis-discovered\/","title":{"rendered":"Video: Key cause of pelvic pain for women with endometriosis discovered"},"content":{"rendered":"<p>[vc_row enable_content_animation=&#8221;yes&#8221; animation_preset=&#8221;Fade In Left&#8221;][vc_column]<style>.ld_spacer_69d46278eba56{height:32px;}<\/style>\n<div class=\"ld-empty-space ld_spacer_69d46278eba56\"><span class=\"liquid_empty_space_inner\"><\/span><\/div>[\/vc_column][\/vc_row][vc_row el_id=&#8221;transcript&#8221;][vc_column][vc_column_text]<div class=\"lyte-wrapper\" title=\"New study finds key cause of pelvic pain for women with endometriosis\" style=\"width:640px;max-width:100%;margin:5px auto;\"><div class=\"lyMe\" id=\"WYL_QUO2sn6-1xI\"><div id=\"lyte_QUO2sn6-1xI\" data-src=\"https:\/\/www.vitalhealth.com\/wp-content\/plugins\/wp-youtube-lyte\/lyteCache.php?origThumbUrl=https%3A%2F%2Fi.ytimg.com%2Fvi%2FQUO2sn6-1xI%2Fhqdefault.jpg\" class=\"pL\"><div class=\"tC\"><div class=\"tT\">New study finds key cause of pelvic pain for women with endometriosis<\/div><\/div><div class=\"play\"><\/div><div class=\"ctrl\"><div class=\"Lctrl\"><\/div><div class=\"Rctrl\"><\/div><\/div><\/div><noscript><a href=\"https:\/\/youtu.be\/QUO2sn6-1xI\" rel=\"nofollow\"><img decoding=\"async\" src=\"https:\/\/www.vitalhealth.com\/wp-content\/plugins\/wp-youtube-lyte\/lyteCache.php?origThumbUrl=https%3A%2F%2Fi.ytimg.com%2Fvi%2FQUO2sn6-1xI%2F0.jpg\" alt=\"New study finds key cause of pelvic pain for women with endometriosis\" width=\"640\" height=\"340\" \/><br \/>Watch this video on YouTube<\/a><\/noscript><\/div><\/div><div class=\"lL\" style=\"max-width:100%;width:640px;margin:5px auto;\"><\/div> [\/vc_column_text]<style>.ld_spacer_69d46278ebab6{height:32px;}<\/style>\n<div class=\"ld-empty-space ld_spacer_69d46278ebab6\"><span class=\"liquid_empty_space_inner\"><\/span><\/div>[vc_column_text]<span style=\"font-weight: 400;\">TRANSCRIPT: <\/span><strong>Key cause of <a href=\"https:\/\/www.vitalhealth.com\/conditions-treated\/pelvic-pain-conditions\/pelvic-pain\/\">pelvic pain<\/a> for women with <a href=\"https:\/\/www.vitalhealth.com\/conditions-treated\/pelvic-pain-conditions\/endometriosis\/\">endometriosis<\/a> discovered<\/strong><\/p>\n<p><span style=\"font-weight: 400;\"><span style=\"font-size: 21px;\">Hi, I&#8217;m here with some exciting news. <\/span><\/span><span style=\"font-weight: 400;\">There was actually a study published earlier this month, that is showing one of the key causes of the reason for pelvic pain in women with endometriosis.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This team focused on the type of immune cell; a white blood cell called the macrophage. And macrophage comes from Greek term, <\/span><i><span style=\"font-weight: 400;\">big eater<\/span><\/i><span style=\"font-weight: 400;\">, \u201cmacro,\u201d <\/span><i><span style=\"font-weight: 400;\">big<\/span><\/i><span style=\"font-weight: 400;\"> \u201cphage\u201d <\/span><i><span style=\"font-weight: 400;\">eater<\/span><\/i><span style=\"font-weight: 400;\">. And really, they\u2019re kind of the garbage collectors, or they eat up different things, actually I have a picture here of one eating some bacteria.<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><img decoding=\"async\" class=\"alignnone size-full wp-image-18333\" src=\"https:\/\/www.vitalhealth.com\/wp-content\/uploads\/2019\/07\/1920x1080-macrophage_fighting_bacteria-56a09af03df78cafdaa32cb3.jpg\" alt=\"macrophages: Key cause of pelvic pain for women with endometriosis\" width=\"1920\" height=\"1080\" srcset=\"https:\/\/www.vitalhealth.com\/wp-content\/uploads\/2019\/07\/1920x1080-macrophage_fighting_bacteria-56a09af03df78cafdaa32cb3.jpg 1920w, https:\/\/www.vitalhealth.com\/wp-content\/uploads\/2019\/07\/1920x1080-macrophage_fighting_bacteria-56a09af03df78cafdaa32cb3-300x169.jpg 300w, https:\/\/www.vitalhealth.com\/wp-content\/uploads\/2019\/07\/1920x1080-macrophage_fighting_bacteria-56a09af03df78cafdaa32cb3-1024x576.jpg 1024w, https:\/\/www.vitalhealth.com\/wp-content\/uploads\/2019\/07\/1920x1080-macrophage_fighting_bacteria-56a09af03df78cafdaa32cb3-150x84.jpg 150w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/><\/span><\/p>\n<p><span style=\"font-weight: 400;\">And so, they\u2019ll eat bacteria cells as they\u2019re dying off, and a variety of other things, they kind of clean up the place. And then, depending on where in the body and what the role is, they\u2019ll actually release different substances that help, so in the case if there\u2019s not enough oxygen and a tissue is trying to heal it will stimulate new blood vessel growth. So, they can really be good and helpful in the body. But it turns out that the local environment, the signals can change the behavior of these macrophages. And it turns out that they\u2019re actually drawn into the endometriosis lesions, so if you look in the endometriosis lesions themselves they are packed full of these macrophages.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">And It turns out, they\u2019re kind of macrophages gone bad. Because it turns out that what they\u2019ve discovered is that under the influence of endometriosis the macrophages are then producing what\u2019s called insulin like growth factor 1 or IGF-1. And what that does is stimulate the nerve cells to grow and culture and actually become more sensitive. So it\u2019s a way of creating oversensitivity, kind of like a sunburn inside. And so, this is a great understanding and again, macrophages, if you don\u2019t remember the word, you\u2019ve got \u201cMGB\u201d <\/span><i><span style=\"font-weight: 400;\">macrophages gone bad<\/span><\/i><span style=\"font-weight: 400;\">. So, you know, they can be good, but these are kind of turned into juvenile delinquents, and they\u2019re raising havoc in the pelvis.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">But part of the good news is that this information allows us a new venue of study, to better understand and hopefully provide better treatment. So, both pain relief and maybe even as a way to tag the endo so we can find it and get rid of it one way or another.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">So for you, geekoids out there, the title of the article:\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><a href=\"https:\/\/www.sciencedaily.com\/releases\/2019\/07\/190711141308.htm\"><i><span style=\"font-weight: 400;\">Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis.\u00a0<\/span><\/i><\/a><\/p>\n<p><span style=\"font-weight: 400;\">So, let me know what you think. I know this is getting a little bit more technical, but I\u2019ve always been of the belief that women with endo are very educated, very smart, and very capable. So just trying to pass this information on to you and I think it\u2019s a great study. All right. Take care.<\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row enable_content_animation=&#8221;yes&#8221; animation_preset=&#8221;Fade In Left&#8221;][vc_column]<style>.ld_spacer_69d46278ebaeb{height:32px;}<\/style>\n<div class=\"ld-empty-space ld_spacer_69d46278ebaeb\"><span class=\"liquid_empty_space_inner\"><\/span><\/div><style>.ld_button_69d46278ebb74.btn-icon-solid .btn-icon{background:rgb(79, 218, 145);}.ld_button_69d46278ebb74.btn-icon-circle.btn-icon-ripple .btn-icon:before{border-color:rgb(79, 218, 145);}.ld_button_69d46278ebb74.btn-icon-solid:hover .btn-icon{background:rgb(52, 219, 197);}.ld_button_69d46278ebb74 .btn-icon{font-size:18px;}.ld_button_69d46278ebb74{background-color:rgb(79, 218, 145);border-color:rgb(79, 218, 145);line-height:1.111em !important;font-size:14px !important;letter-spacing:0.1em !important;box-shadow:0px 8px 15px 0px rgba(48,198,168,0.32);}.ld_button_69d46278ebb74:hover{background-color:rgb(52, 219, 197);border-color:rgb(52, 219, 197);}.ld_button_69d46278ebb74 .btn-gradient-bg{background:-webkit-linear-gradient(to right, rgb(79, 218, 145) 0%, rgb(52, 219, 197) 100%);background:linear-gradient(to right, rgb(79, 218, 145) 0%, rgb(52, 219, 197) 100%);}.ld_button_69d46278ebb74 .btn-gradient-bg-hover{background:-webkit-linear-gradient(to right, rgb(52, 219, 197) 0%, rgb(52, 219, 197) 100%);background:linear-gradient(to right, rgb(52, 219, 197) 0%, rgb(52, 219, 197) 100%);}.ld_button_69d46278ebb74 .btn-gradient-border defs stop:first-child{stop-color:rgb(79, 218, 145);}.ld_button_69d46278ebb74 .btn-gradient-border defs stop:last-child{stop-color:rgb(52, 219, 197);}.ld_button_69d46278ebb74:hover .btn-gradient-border defs stop:first-child{stop-color:rgb(52, 219, 197);}.ld_button_69d46278ebb74:hover .btn-gradient-border defs stop:last-child{stop-color:rgb(52, 219, 197);}<\/style><a href=\"https:\/\/www.fasebj.org\/doi\/10.1096\/fj.201900797R\" target=\"_blank\" class=\"btn btn-solid circle btn-bordered border-thin btn-gradient btn-icon-left ld_button_69d46278ebb74 vc_custom_1564109443237\">\n\t<span>\n\t<span class=\"btn-gradient-bg\"><\/span>\t\n\t\t\t\t\t<span class=\"btn-txt\">Click here to read the study<\/span>\n\t\t\t\n\t<span class=\"btn-icon\"><i class=\"fa fa-file-pdf-o\"><\/i><\/span>\t<span class=\"btn-gradient-bg btn-gradient-bg-hover\"><\/span>\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xml:space=\"preserve\" class=\"btn-gradient-border\" width=\"100%\" height=\"100%\">\n\t\t\t      <defs>\n\t\t\t        <linearGradient id=\"svg-border-69d46278ebc6d\" x1=\"0%\" y1=\"0%\" x2=\"100%\" y2=\"0%\">\n\t\t\t          <stop offset=\"0%\" \/>\n\t\t\t          <stop offset=\"100%\" \/>\n\t\t\t        <\/linearGradient>\n\t\t\t      <\/defs>\n\t\t\t      <rect x=\"0.5\" y=\"0.5\" rx=\"17%\" ry=\"50%\" width=\"100%\" height=\"100%\" stroke=\"url(#svg-border-69d46278ebc6d)\"\/>\n\t\t\t    <\/svg>\t<\/span>\n<\/a>\n[\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row enable_content_animation=&#8221;yes&#8221; animation_preset=&#8221;Fade In Left&#8221;][vc_column][\/vc_column][\/vc_row][vc_row el_id=&#8221;transcript&#8221;][vc_column][vc_column_text] [\/vc_column_text][vc_column_text]TRANSCRIPT: Key cause of pelvic pain for women with&#8230;<\/p>\n","protected":false},"author":2,"featured_media":7229,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"video","meta":{"footnotes":""},"categories":[92,81,104],"tags":[144,357],"class_list":["post-18341","post","type-post","status-publish","format-video","has-post-thumbnail","hentry","category-endometriosis-pelvic-pain","category-pelvic-pain","category-vital-health-news","tag-endomentriosis","tag-pelvic-pain-causes","post_format-post-format-video"],"_links":{"self":[{"href":"https:\/\/www.vitalhealth.com\/wp-json\/wp\/v2\/posts\/18341","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vitalhealth.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vitalhealth.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vitalhealth.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vitalhealth.com\/wp-json\/wp\/v2\/comments?post=18341"}],"version-history":[{"count":0,"href":"https:\/\/www.vitalhealth.com\/wp-json\/wp\/v2\/posts\/18341\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vitalhealth.com\/wp-json\/wp\/v2\/media\/7229"}],"wp:attachment":[{"href":"https:\/\/www.vitalhealth.com\/wp-json\/wp\/v2\/media?parent=18341"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vitalhealth.com\/wp-json\/wp\/v2\/categories?post=18341"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vitalhealth.com\/wp-json\/wp\/v2\/tags?post=18341"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}