Libby Hopton | Vital Health Endometriosis Center https://www.vitalhealth.com A women's healthcare, endometriosis, and pelvic pain treatment center Fri, 26 Apr 2019 21:47:46 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.4 What is Hormone Therapy and Should it be Used to Treat Endometriosis? https://www.vitalhealth.com/endo-blog/hormone-therapy-used-treat-endometriosis/ https://www.vitalhealth.com/endo-blog/hormone-therapy-used-treat-endometriosis/#comments Wed, 28 Jan 2015 20:25:58 +0000 http://test.vitalhealth.com/?p=10082 The post What is Hormone Therapy and Should it be Used to Treat Endometriosis? appeared first on Vital Health Endometriosis Center.

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The typical medical treatment for endometriosis provided by most OBGYNs consists of manipulating a woman’s hormones, primarily her estrogen and/or progesterone levels. The rationale behind this treatment is that estrogen tends to stimulate the growth of endometriosis and progesterone is believed to balance or stabilize the effect of estrogen. In a very simple example, one can think of estrogen as fertilizer for the lawn and progesterone as the lawn mower. The goal of medical treatment of endometriosis is to increase the ratio of progesterone to estrogen (progesterone-only treatment), decrease the amount of both estrogen and progesterone (combinational birth control pills) or to eliminate estrogen from the body (GnRH agonist treatments such as Lupron and Zoladex).

Unfortunately, all hormone therapies commonly employed to treat endometriosis are fairly crude and are frequently associated with unacceptable side effects, making these medications difficult to tolerate. Some patients find the side effects even more debilitating than the symptoms of the disease itself. Hormone therapies do not provide a cure for the disease, are only effective in a portion of endometriosis patients, and even when this treatment option provides relief the results are typically short-lived and symptoms return. Furthermore, hormone therapies are not appropriate in patients presenting with infertility or who are trying to conceive. Even use of a GnRH agonist such as Lupron that causes a temporary medical menopause is frequently ineffective in managing endometriosis as endometriotic tissue itself can produce its own source of estrogen, allowing it to remain active and symptomatic despite the treatment.

When should hormone therapies be considered?

If hormone therapies are only temporarily effective in some patients and do not make the endometriosis go away nor necessarily stop the disease in its tracks (treating the symptoms but not the disease), why are they so commonly prescribed?

When a patient first presents with pelvic pain, and in particular period pain, the doctor and patient face a dilemma: How long should her symptoms be managed symptomatically (via medical therapy) and at what point should more invasive treatment options be considered (such as laparoscopic surgery) to actually diagnose and treat any underlying disease? On the one hand the patient wants to avoid unnecessarily invasive treatments and the risks associated with surgery (albeit minimal,) yet on the other hand she also wants to get to the root of her problem so that it can be effectively treated and she can get on with her life. This is obviously a very personal decision that needs to be made based on the severity of symptoms and the individual needs and priorities of the patient. Importantly, however, the patient needs to be informed of her options so that she can play an active role in the decision-making process.

Prescribing hormone therapies requires limited expertise and is a treatment option that is readily available to all. Surgery, in contrast, may require a level of expertise that most OBGYNs do not have. Moreover, if a patient is presenting with erratic and painful menstrual periods, a prescription of birth control pills may lighten, regulate and shorten her periods, easing her pain. It is when a patient keeps returning to her doctor complaining of the same symptoms despite trying different hormone therapies or cannot tolerate the side effects, that it is time to consider other treatment options.

Adenomyosis

A condition that is common among women with endometriosis is adenomyosis. Adenomyosis is when endometriotic tissue is found within the muscular walls of the uterus. Typically these areas of rogue tissue are scattered diffusely throughout the muscular uterine walls and so are not amenable to surgical removal. Endometriosis patients who also have suspected adenomyosis may find that some of their pelvic pain persists despite endometriosis excision surgery. While surgery to destroy or sever the nerves that innervate the uterus may help reduce this residual uterine pain, in most cases the only curative surgery for adenomyosis is hysterectomy (removal of the uterus). Obviously, many women will not be a position to undergo hysterectomy because they wish to retain their fertility. In these patients, conservative management of the chief symptoms of adenomyosis (pain and abnormal uterine bleeding) with hormone therapy provides an important alternative.

Pre-operative ovarian suppression

Another example where hormone therapy may be appropriate is in managing pain in patients who are waiting for surgery. For example, a teenage patient who plans her surgery during her school vacation so as not to disrupt her studies may benefit from hormone therapy to manage her symptoms and help her function in the mean time. Importantly, however, it is best that the patient is not on ovarian suppressive therapy shortly before or at the time of her surgery as this can hamper the surgeon’s ability to visualize all areas of disease. Ideally, all ovarian suppressive therapy should have be discontinued 6-8 weeks prior to surgery.

Should hormone therapies be prescribed following surgery to prevent recurrence?

If a patient has undergone the complete surgical removal of her endometriosis and her pain has been resolved there is no clinical indication for continued use of hormone therapies (other than for contraceptive purposes). Post-operative hormone therapy has not been found to reduce the rate of symptom nor disease recurrence. Recurrence of endometriosis rarely occurs following the complete excision of the disease regardless of whether the patient follows up surgery with hormone therapy.

Post-operative ovarian suppression following cystectomy

Some surgeons recommend post-operative hormone therapy following endometrioma (cystic ovarian endometriosis) removal (cystectomy) with the hope that ovarian suppression will reduce the risk of recurrence of the endometrioma(s). Research into this, however, has been inconclusive. Another reason for post-operative ovarian suppression following endometrioma removal is to give time for the ovary to heal before ovulation recommences, which might otherwise cause additional pain during post-operative healing.

Further reading

For more information on different types of hormone therapy, common side effects and their efficacy in treating endometriosis and adenomyosis,, check out Dr. Cook’s in-depth patient guide to hormone therapy treatments.

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Management of Pelvic Pain in Women with Endometriosis https://www.vitalhealth.com/endo-blog/management-pelvic-pain-women-endometriosis/ https://www.vitalhealth.com/endo-blog/management-pelvic-pain-women-endometriosis/#comments Wed, 28 Jan 2015 19:22:30 +0000 http://test.vitalhealth.com/?p=10058 The post Management of Pelvic Pain in Women with Endometriosis appeared first on Vital Health Endometriosis Center.

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Adequate management of pain is paramount in women with endometriosis, due to the chronic and debilitating nature of this painful condition. The type of treatments offered will depend on the type of pain, its severity and duration, and the specific needs and wishes of the patient.

What can be done about my pain?

Our aim is to offer permanent relief and resolution of pain through surgical and non-surgical interventions (excision surgery, nutritional counseling, pelvic physical therapy etc.). In some cases, however, short-term or ongoing pain management is required to allow our patients to function. Not all sources of pain can be resolved by therapeutic intervention and in some cases definitive treatments, such as hysterectomy for uterine disease, may not be desired due to a wish to preserve fertility. Instead, ongoing palliative management in the form of prescription and non-prescription drugs and interventional pain management (nerve blocks, pain pumps and catheters) may be required. Interventional treatments may warrant the specialist expertise of a pain-management physician who will work in close coordination with the rest of the patient’s healthcare team.

Non-prescription (over-the-counter) pain medications

Common non-prescription pain medications used by pelvic pain patients include Acetaminophen or Tylenol and non-steroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen and naproxen, which suppress inflammation. Care needs to be taken to not exceed safe daily dosages of pain medication and, in particular, when combining different non-prescription and prescription drugs. It is important for your safety that even over-the-counter medications are disclosed and carefully discussed with your doctor when considering pain management options.

Prescription pain medications

Prescribed pain medications include prescription NSAIDS and narcotics. Narcotics can be short acting (e.g., hydrocodone, oxycodone and hydromorphone) or long acting (e.g., morphine and long-acting oxycodone). Narcotic pain medications work by slowing down or stopping the signals from the nerves to the brain. The choice of narcotics prescribed will depend on whether your pain is acute (such as post-operative pain) or chronic (ongoing pain).

Pain-narcotic contract

If a patient receives prescription-narcotic pain management, she will be required to enter into a pain-narcotic contract which specifies what she can and cannot do while taking prescription-narcotic pain medications. All members of her healthcare team are aware of this contract and regular meetings are held among the staff to discuss and monitor the patients who are receiving prescription-narcotic pain management.

Interventional pain management treatments

Interventional pain management treatments for long-term pain include pain pumps (an implantable pain-management device), spinal cord stimulators (pain catheters), trigger-point injections or nerve blocks (temporary numbing injections to painful areas or overly sensitive nerves), and radiofrequency ablation (RFA), where targeted nerves are “stunned”, offering more prolonged relief than nerve blocks.

At Vital Health we offer an array of options to both resolve your pain and to manage acute and chronic pain. We firmly believe that no woman should suffer from pelvic pain and we strive to provide optimal relief to each and every patient who comes to us for help. Even when a patient suffers from intractable pain that does not respond to surgical and non-surgical intervention, ongoing pain can be managed with a variety of palliative approaches, offering hope, relief, and restoring your quality of life.

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What Happens During a Diagnostic Laparoscopy? https://www.vitalhealth.com/endo-blog/happens-diagnostic-laparoscopy/ https://www.vitalhealth.com/endo-blog/happens-diagnostic-laparoscopy/#respond Mon, 26 Jan 2015 22:21:15 +0000 http://test.vitalhealth.com/?p=10027 The post What Happens During a Diagnostic Laparoscopy? appeared first on Vital Health Endometriosis Center.

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Diagnostic laparoscopy is a form of minimally invasive abdominal surgery that is performed to investigate potential sources of pelvic pain and infertility. During the procedure, the inside of the pelvic and abdominal cavities are carefully inspected for any abnormalities, such as endometriosis and adhesions. Diagnostic laparoscopy is typically performed under general anesthesia [1] and is commonly combined with therapeutic laparoscopy to treat any disease that is found.

What happens during the procedure?

First of all, the patient is put to sleep, her airways are intubated, her vital signs monitored and her bladder emptied with a catheter. The surgeon then performs a pelvic exam to check for any abnormalities. If a bladder condition is suspected (such as interstitial cystitis) a cystoscopy may be performed (the bladder is slowly filled with saline solution and a small camera is inserted to inspect the inside of the bladder for abnormalities). If abnormalities are suspected involving the inside of the uterus a hysteroscopy may be performed (a small camera is introduced through the cervix into the uterus to inspect the uterine cavity and obtain biopsies). An instrument called a uterine manipulator is then inserted through the cervix and into the uterine cavity. The uterine manipulator enables the surgeon to adjust the positioning of the uterus within the pelvis enabling complete visualization of the pelvic structures. Endometriosis often involves the tissue between the uterus and the large bowel (referred to as the Pouch of Douglas or the posterior cul-de-sac). In order to inspect this area during surgery, the uterus needs to be elevated forward.

After the placement of the uterine manipulator, a hollow needle is introduced to the pelvis through a tiny incision and the pelvic cavity is slowly insufflated (inflated) with CO2 gas. Normally the pelvic structures all rest together. The use of gas provides more space within the pelvis, separating the various structures and enabling visualization by the surgeon. Three small incisions are then made in the patient’s lower abdomen (these incisions are sufficient for both the diagnosis and treatment of endometriosis). One incision is made in the umbilicus (the belly button) and two are made beneath the bikini line, one on the right and one on the left. [2] After surgery the scars where these incisions were made will fade in time until they are barely noticeable and will be fully concealed by a bikini. A trocar (a cylindrical sheath through which the instruments are placed) is inserted through each incision. The laparoscope is introduced through the umbilical trocar (the trocar that is inserted through the patient’s belly button). A laparoscope is a thin fiber-optic tube with a camera integrated at the tip, which is connected to large video monitors so that the surgeon can inspect the inside of the pelvis. Surgical instruments are introduced through the other two trocars. These instruments may be used to grasp and move the pelvic structures, to irrigate (clean) surfaces, to suction (remove) free fluid from the bottom of the pelvis, and to dissect (separate) organs and structures that are fused together by adhesions (scar tissue) to allow the surgeon to inspect all surfaces.

The entire pelvic cavity is carefully examined with the tip of the laparoscope held close to the surface of the peritoneum (a thin layer of tissue that cloaks the pelvic structures). This enables the surgeon to detect any abnormalities, no matter how subtle. The pelvic structures, including the appendix, intestines, and diaphragm, are carefully examined for possible disease and adhesions. Any abnormalities in the appearances and consistency of the uterus are noted.

What are the challenges in identifying all areas of endometriosis?

The inside of the body is not like an empty room (where it’s easy to see if there is anything on the floor or walls). Instead, there are a lot of folds and nooks and crannies, and the search for endometriosis is more like trying to find a penny amongst a bunch of wadded up, unfolded cloths. With endometriosis, very small, difficult-to-see lesions can cause excruciating pain. When the end of the laparoscope is very close to the tissue, the laparoscope magnifies it. But this also decreases the area that is seen, similar to the effect of looking through a telescope or a set of binoculars.

A surgeon must be very thorough and meticulous, and use a systematic approach in looking for endometriosis. He or she also needs to understand the many different appearances of endometriosis, and work with an excellent pathologist who does not overlook mild endometriosis. The visual appearance of endometriosis is highly varied: The lesions can be dark, pigmented lesions, similar to a blood blister, or clear, vesicular lesions, appearing like miniature water balloons. It can also look like specks of salt or even leathery scar tissue. Some endometriosis is hard to see, but if the proper time and magnification are used, it can be found. In addition, scar tissue in an endometriosis patient should be considered and treated as endometriosis until proven otherwise.

The pathologist is an unseen and largely unappreciated member of the endometriosis team. If the pathologist is not meticulous in his or her examination of the tissue, then endometriosis will be missed, and the feedback to the surgeon will be false. Worst of all for the patient, the surgeon will leave endometrial lesions behind because the pathologist has incorrectly told the surgeon that this appearance is not endometriosis, when in fact it is. I work with a physician whom I believe to be one of the best endometriosis pathologists in the country. He has a lot of respect for endometriosis, and is very meticulous in looking for the disease. He takes extra steps in preparing the tissue, which helps to maximize the chance of finding all the endometriosis that is present.

Will diagnostic laparoscopy be proceeded by therapeutic laparoscopy?

After the pelvis has been carefully examined, the surgeon then proceeds to surgically treat any areas of suspected disease. The process of treating any abnormal findings is referred to as a therapeutic laparoscopy. Diagnostic and therapeutic laparoscopy are typically combined, although some surgeons first perform a diagnostic laparoscopy to assess the severity of the disease and then either plan in a further surgery to treat the disease or else refer the patient to a specialist. Dr. Cook always diagnoses and meticulously treats all areas of abnormal tissue during the same one procedure.

What happens once the surgery is complete?

Once the surgery is complete, the instruments and trocars are removed, the abdomen is carefully deflated and the incisions are glued or sutured closed and small dressings are applied. The patient is then taken to recovery and closely monitored. Anti-nausea and pain meds are provided via IV to keep the patient comfortable. Following surgery Dr. Cook admits his patients overnight so that they receive optimal management of their post-operative pain. During the first hours following surgery you may feel groggy and tired and your throat may feel sore from the intubation tube. The fatigue may last for some days to several weeks, depending on the length of surgery and your physical condition prior to surgery. In most cases any post-operative pain is well managed by the IV, PCA pump and orally administered pain medications while in hospital and the pain medications prescribed following discharge. Residual gas from the surgery may take some time to dissipate, causing temporary shoulder tip pain but usually resolves within a few days. Likewise, the incision sites may be tender and bruised for the first week or two after surgery but will recover in time. Slowly you will find yourself returning to your normal activities. The length of recovery will depend on the patient’s general health as well as on the extent of surgery that has been required.

Dr. Cook and his team carefully follow up all surgery patients to make sure they are comfortable and recovering well. If any concerns arise, the Vital Health team is on hand to help you.

How effective is a diagnostic laparoscopy at identifying endometriosis?

In the capable hands of an endometriosis specialist diagnostic laparoscopy is a highly accurate method of identifying any abnormal tissue and confirming the presence or absence endometriosis. Surgeons who are less familiar with endometriosis, however, may fail to recognize subtle areas of disease and may misinterpret the clinical significance of dense adhesions (which to a specialist is often a sign of significant underlying invasive disease). An unfortunate outcome is where a patient with endometriosis is incorrectly told by her surgeon that she does not have the disease, further delaying correct diagnosis and treatment. It takes a trained eye to recognize endometriosis in all its forms and make an accurate diagnosis. It is therefore important to request that your surgeon documents the surgery by taking photos and/or providing you with a complete digital copy of your procedure on DVD. This way, you can seek a second opinion if you suspect disease has been missed. Ideally, it is best to find an endometriosis surgical specialist to conduct your surgery. Dr. Cook records all of his surgeries and provides his patients with comprehensive surgical photos and a complete copy of the procedure on DVD on request.

Dr. Cook and his team performing a diagnostic laparoscopy.

Notes

  1. Occasionally patient-assisted laparoscopy (PAL) will be performed, in which the patient is awake during the procedure and can guide the surgeon to the source of her pain. PAL may be indicated if previous laparoscopic surgery has failed to identify and resolve the patient’s pain.
  2. In patients with symptoms suggestive of diaphragmatic endometriosis an extra incision may be required in the upper right quadrant of the abdomen (just under the right rib margin) in order to fully visualize the right side of the diaphragm behind the liver.

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